diff --git a/src/libslic3r/Config.cpp b/src/libslic3r/Config.cpp
index 2deaf1ee7..d3ff332ed 100644
--- a/src/libslic3r/Config.cpp
+++ b/src/libslic3r/Config.cpp
@@ -451,6 +451,17 @@ void ConfigBase::apply_only(const ConfigBase &other, const t_config_option_keys
         if (my_opt == nullptr) {
             // opt_key does not exist in this ConfigBase and it cannot be created, because it is not defined by this->def().
             // This is only possible if other is of DynamicConfig type.
+            if (auto n = opt_key.find('#'); n != std::string::npos) {
+                auto opt_key2 = opt_key.substr(0, n);
+                auto my_opt2 = dynamic_cast<ConfigOptionVectorBase*>(this->option(opt_key2, true));
+                if (my_opt2) {
+                    int index = std::atoi(opt_key.c_str() + n + 1);
+                    auto other_opt = other.option(opt_key2);
+                    if (other_opt)
+                        my_opt2->set_at(other_opt, index, index);
+                    continue;
+                }
+            }
             if (ignore_nonexistent)
                 continue;
             throw UnknownOptionException(opt_key);
diff --git a/src/slic3r/GUI/Tab.cpp b/src/slic3r/GUI/Tab.cpp
index 05f6dae2c..5bf80b4a0 100644
--- a/src/slic3r/GUI/Tab.cpp
+++ b/src/slic3r/GUI/Tab.cpp
@@ -1739,6 +1739,7 @@ void Tab::apply_searcher()
 
 void Tab::cache_config_diff(const std::vector<std::string>& selected_options)
 {
+    m_cache_options = selected_options;
     m_cache_config.apply_only(m_presets->get_edited_preset().config, selected_options);
 }
 
@@ -1751,8 +1752,9 @@ void Tab::apply_config_from_cache()
         was_applied = static_cast<TabPrinter*>(this)->apply_extruder_cnt_from_cache();
 
     if (!m_cache_config.empty()) {
-        m_presets->get_edited_preset().config.apply(m_cache_config);
+        m_presets->get_edited_preset().config.apply_only(m_cache_config, m_cache_options);
         m_cache_config.clear();
+        m_cache_options.clear();
 
         was_applied = true;
     }
@@ -4737,11 +4739,15 @@ bool Tab::select_preset(std::string preset_name, bool delete_current /*=false*/,
                 { Preset::Type::TYPE_FILAMENT,      &m_preset_bundle->filaments,    ptFFF },
                 //{ Preset::Type::TYPE_SLA_MATERIAL,  &m_preset_bundle->sla_materials,ptSLA }
             };
+            Preset *to_be_selected = m_presets->find_preset(preset_name, false, true);
+            ConfigOptionStrings* cur_opt2 = dynamic_cast <ConfigOptionStrings *>(m_presets->get_edited_preset().config.option("printer_extruder_variant"));
+            ConfigOptionStrings* to_select_opt2 = dynamic_cast <ConfigOptionStrings *>(to_be_selected->config.option("printer_extruder_variant"));
+            no_transfer = cur_opt2->values != to_select_opt2->values;
             for (PresetUpdate &pu : updates) {
                 pu.old_preset_dirty = (old_printer_technology == pu.technology) && pu.presets->current_is_dirty();
                 pu.new_preset_compatible = (new_printer_technology == pu.technology) && is_compatible_with_printer(pu.presets->get_edited_preset_with_vendor_profile(), new_printer_preset_with_vendor_profile);
                 if (!canceled)
-                    canceled = pu.old_preset_dirty && !pu.new_preset_compatible && !may_discard_current_dirty_preset(pu.presets, preset_name) && !force_select;
+                    canceled = pu.old_preset_dirty && !pu.new_preset_compatible && !may_discard_current_dirty_preset(pu.presets, preset_name, no_transfer) && !force_select;
             }
             if (!canceled) {
                 for (PresetUpdate &pu : updates) {
diff --git a/src/slic3r/GUI/Tab.hpp b/src/slic3r/GUI/Tab.hpp
index c95263051..0dfb83f8d 100644
--- a/src/slic3r/GUI/Tab.hpp
+++ b/src/slic3r/GUI/Tab.hpp
@@ -274,6 +274,7 @@ protected:
     m_highlighter;
 
 	DynamicPrintConfig 	m_cache_config;
+    std::vector<std::string> m_cache_options;
 
 
 	bool				m_page_switch_running = false;